Health results (also DM!!) in the Wolfdog.org database

[mijke]

Great when we can get such a database!!

Originally Posted by michaelundinaeichhorn

And looking a the gene test like DM and Dwarf, all researchers told us not to publish any results because of witch-hunts and lowering of the gene pools.

I don't agree with this. I also did hear other opinions of veterinary professors and genetic specialists.
And for example because of not testing for Dwarfism, not sharing test info, till today dwarfs are born. (and because dwarfism also can cause very small litters, dead born pups, puppy dead in first week, there maybe are a lot more dwarfism genes in the population)
In the past there were also witch-hunts about HD results (and breeders did try to hide results) Now it is more common to share HD info and a lot of puppy buyers even ask breeders for the HD results.
And yes unfortunately there are still some breeders who don't make HD results and are selling "ferry tails" to puppy buyers (CsW is e very natural breed and HD does not exists in this breed)

Originally Posted by Admin

There are four options planned:
1- the result will be visible to everyone
2- the results will be visible only to registered breeders
3- the results will be visible to "trusted" people
4- the result will be not visible and used only for statistics
(exception is HD/ED - it will be showed to everyone).

About point 3.: I was thinking to give access to people chosen by the official breed clubs (breeding comittee members, a.s.o). They will be able to see more results than even registered breeders (but still the will be not able to see "hidden" results)

That seems a very good option for the moment. But I hope in future publishing all test results will be as normal as now for HD/ED.

Originally Posted by GalomyOak

I'd love to see Penn-Hip results listed in the database eventually, as this is becoming an ever popular test in the US for hips - when we have 20 CSVs tested, we will have a control sample to make official breeding recommendations from, for the breed. Penn - does not have an online database.

Also very good suggestion!

Originally Posted by Admin

I see that they are declared as "clear" only if "all three (sire/dam/offspring) have been DNA identity profiled and parentage verified." We can also make such rule for Wolfdog.org database - even if till now there are no dogs which fulfill such conditions..

That would be great!

Originally Posted by Hanka

And what about "only DNA profil" of dog? It will be more and more important, if some "breeders" mix wolfdogs or make falses in pedigries .....

But... there are unfortunately countries (like mine) where owners can send a swab by themselves for DNA to the national breed organization RVBH without any official checking of the dog!

Originally Posted by GalomyOak

Owners of dogs with abnormal results are given the option to publish their dogs, or not. As a club, I think we will push to have transparency and openness in declaring results to further research, and strengthen our breeding program in the US.

As Dutch club we also push to have transparency. On this moment we publish test results conform Wolfdog-healthinfo.org (owner can choose: with or without dog name).

Originally Posted by Mikael

But what is MDR1 and MH ???

MDR1= Multi Drug Resistance and MH= Maligne Hypothermia

[mijke]

About DNA identity profile :

On this moment all profiles conform ISAG 2006 norms are accepted.

But: All dogs who have an official DNA identity that was made before 2007 (by an other ISAG norm) are not validated anylonger!!

The technical aspects around DNA identity are improved last years.
That is why now only ISAG 2006 is exepted.

So it is a pity for all breeders/owners (like me for example ) who did let make an official DNA profile of all their dogs before 2007
These certificates are of no use any longer

[Mikael]

Originally Posted by mijke

About DNA identity profile :

So it is a pity for all breeders/owners (like me for example ) who did let make an official DNA profile of all their dogs before 2007
These certificates are of no use any longer

But way ??? What has change ???

Best regards / Mikael

[of_Mercedes_Dream]

Originally Posted by mijke

About DNA identity profile :

On this moment all profiles conform ISAG 2006 norms are accepted.

But: All dogs who have an official DNA identity that was made before 2007 (by an other ISAG norm) are not validated anylonger!!

The technical aspects around DNA identity are improved last years.
That is why now only ISAG 2006 is exepted.

So it is a pity for all breeders/owners (like me for example ) who did let make an official DNA profile of all their dogs before 2007
These certificates are of no use any longer

For Belgium it's really important that the DNA isag 2006 will be in the databank. St Hubertus (fci) does not allow to breed with dogs without this code. No dna is no pedigree.
Patrick

[Mikael]

Originally Posted by of_Mercedes_Dream

For Belgium it's really important that the DNA isag 2006 will be in the databank. St Hubertus (fci) does not allow to breed with dogs without this code. No dna is no pedigree.
Patrick

That sound god, can you send me more info about this to my e-mail...
If FCI can demand it in Belgium, way not ALL FCI contry´s

Very best regards / Mikael

[saschia]

Originally Posted by mijke

MDR1= Multi Drug Resistance

Well, I can imagine multi-drug resistance in cancer cells and in bacteria, but in dogs???

Malignant hypertermia - is there a valid test? As far as I know, malignant hyperthermia is caused by mutations on RyR1 gene... If it behaves similarly to RyR2 gene, than any testing is quite a lot of work, as there are more than 50 different RyR2 mutations (causing CPVT) in people identified so far, in 3 different regions of the gene, and RyR1 as well as RyR2 are huge genes. Or is it identified by encountering the problem and subsequent muscle biopsy?

[Nebulosa]

Originally Posted by saschia

Well, I can imagine multi-drug resistance in cancer cells and in bacteria, but in dogs???

The same protein encoded by this gene is associate with the blood-brain barrier, this protein is responsible to pump some toxines out of the brain, this defect turns some drugs like Ivermectine letal to these dogs.

[yukidomari]

Originally Posted by saschia

Well, I can imagine multi-drug resistance in cancer cells and in bacteria, but in dogs???

Unfortunately Australian Shepherds are in my experience the breed with the highest incidence of MDR1 mutation. Chemicals commonly found in heartworm preventatives can be dangerous when applied on dogs with MDR1 mutations (along with other chemicals). Lots of Aussie owners we know purposely stay away from medications with Ivermectin in it, even if they have not tested the specific dogs for MDR1 mutation.

[saschia]

Thanks for clearing up. So it is not resistance, but sensitivity, actually... Very interesting...

[michaelundinaeichhorn]

Is there any known wolfdog that has shown MH or MDR1 mutation? I know that this can occure in GSH but never heard of a wolfdog.

[michaelundinaeichhorn]

Originally Posted by mijke

And for example because of not testing for Dwarfism, not sharing test info, till today dwarfs are born. (and because dwarfism also can cause very small litters, dead born pups, puppy dead in first week, there maybe are a lot more dwarfism genes in the population)

As you wrote, this is not because of not publishing named results in an open forum but due to not testing and not sharing results. As you know did we share the results of Farouk but I am not happy when he is named negative in the forum by his breeder, as it is of no use for the breed if his brothers come to get more used just because he is negative and that is the reaction many people show. It is a stupid reaction but it is the reaction experience shows. As long as there are only few dogs tested and you don´t have to test to breed, there will be breeders that don´t test because they are afraid to get problems and be blamed for using a carrier at all, we have already had this situation in this forum. And there will be also the effect that people will select their dogs for only one gene-test even if they don´t plan to breed.

The case I mentioned was the only breeder in his country with tested dogs, he mated DM/N with N/N and was blamed by the regional wolfdog club (with no tested dogs) for using them, this club plans to only use N/N dogs.

I wouldn´t have get the support of the Slovakian Club and wouldn´t get blood from Hungary if I would name the results of anybody in this forum.

The time to publish is when there is the main population of breeding dogs tested and the Clubs request testing.

Our actual litter is of dogs that are tested and we wouldn´t mate with or to an untested dog, we even pay the test for the stud dog if costs are a problem but we will not publish named results.
As I wrote before it depends to the owner, not to the breeder and not to the owners of a website.

Ina

[Mikael]

Originally Posted by michaelundinaeichhorn

Our actual litter is of dogs that are tested and we wouldn´t mate with or to an untested dog...

Yes, this is what is important !

But it is important to share for statistic to
Can we schare statistic today but not share the name of the dogs ???

Best regards / Mikael

[wolfin]

Originally Posted by Mikael

Yes, this is what is important !

But it is important to share for statistic to
Can we schare statistic today but not share the name of the dogs ???

Best regards / Mikael

i think this Ina and make - share results but without name. and this can make and others, see in mijke wolfdog.healt web site.

[Mikael]

Originally Posted by wolfin

i think this Ina and make - share results but without name. and this can make and others, see in mijke wolfdog.healt web site.

OK, is this statistic automatic from laboratory ? Or must the over send info for the statistic separately and say "Do not show name of the dog" ???

If automatic, from which laboratory ??? Not all I guess

Very best regards / Mikael

[wolfin]

Originally Posted by Mikael

OK, is this statistic automatic from laboratory ? Or must the over send info for the statistic separately and say "Do not show name of the dog" ???

If automatic, from which laboratory ??? Not all I guess

Very best regards / Mikael

i think about this can better say Mijke when she admin this web site.

[mijke]

We only receive copy of the document of an owner not of a lab!