Dwarfism test for CSW?

mijke · 13-09-2008, 23:44

As some of you may already know the university in Utrecht (NL) has developed a test, which can determine the mutation of the gene that is responsible for dwarfism (achondroplasia).

Dwarfism is a nasty disorder which you don’t wish upon any breeder or dog. A dwarf has a badly developed hypophysis, which means that certain hormones (such as growth hormones) are not produced. Due to the shortage of the production of the thyroid stimulating hormone, they have a slow functioning thyroid. Besides the fact that these dogs stay small, they are also haunted by various nasty side effects (e.g. baldness, itching, inflammations, malfunctioning of the liver and kidneys, slow behaviour) when they are not treated with medicines on a daily basis.

One case of dwarfism is known to me within the CSW breed. Because this kind of gene mutations never come incidentally, there must have been born more dwarf CSW. (If one dwarf dog is born, then it means that approximately 18% of the dogs is carrying the gene.)
But not always dwarfs are recognised in a litter… Dead born pups and pups behind in growth are often not recognised as dwarfs. Moreover, 90% of the living born dwarfs dies in the first week.

With the Saarloos wolfdog it has already become clear that this disorder appears much more than ever thought.

Based on the genetic basis of CSW, it is feared that it could be the same in the CSW breed.
But with the development of the dwarfism test it has become possible to prevent further dwarfs being born within certain breeds!

I’ve heard from the researchers at the Utrecht university (who are working on this subject since years), that the mutation that leads to dwarfism in the Saarlooswolfdog breed is identical to the one of the German shepherd.
So the gen test is exactly the same for the German shepherd as well as the Saarlooswolfdog.

Based on the fact that the CSW also has the German shepherd as an ancestor, it is certainly feasible that the genetic background of dwarfism in the CSW breed is exactly the same as with the Saarloos wolfdog.
In this case the same dwarfism test can be used for the CSW breed as well!

But….
To see if the genetic mutation of the CSW has the same background, it must be determined that at least one dog is carrying this mutation.

Therefore
Blood is needed from at least one dog which is suffering from dwarfism, or which is certainly carrying the mutated gene by being the parent of a dwarf dog.

Thus:
I am doing an urgent appeal for the health of the breed to all readers of this forum to contact me by personal message or by e-mail ([email protected]) in case you know somebody who has a CSW with dwarfism or a parent of one.

I do not care about the names of the dogs!
My only hope is to find owners who are willing to cooperate, to determine if the new dwarfism test is also valid for CSW

I can give those owners more information after they have contact me.

With this request I do not intent to start up suggestions or speculations about the possibility that a breeder may has had a dwarf in his or her litter!
The only request I have is to connect me with owners of a dwarf TW or owners who have a parent of dwarf CSW.

If we find owners who are willing to cooperate and the results of the tests are known, I will of course inform everyone here at the forum.

In advance I would like to thank you for your cooperation!

Best regards,
Mijke

GalomyOak · 14-09-2008, 00:07

Very nice!!! I hope you find someone that will help you!

Marcy

loco · 25-09-2008, 14:48

I have found this link.
http://www.accdata.co.uk/dwarfism/index.html
and then to the field the history of dwarfism.

Only CONSEAL and DENIAL by the breeders off the GS

.
Hope the CSW world is very diffrent

, and the test is very soon availble

.

Groette Martine.

Hanka · 25-09-2008, 20:30

Hello Mijke,
I have seen this picture on saarlos page, it is very interest for me. Please can you write me (maybe privat message) in what litter you have seen this csw? Maybe we can look for in "blood" of this puppy. Have you got any fotos? I have seen a some similar case, but on foto of saarlos it looks very diferent.....more worse....thanks Hanka

Hanka · 25-09-2008, 20:32

And second question: is it possible- this puppy was from some "pure breed" breeding

of csw in west Evropa? Everybody know, there is possible everything. Can there be any saarlos in population of csw?

loco · 25-09-2008, 21:09

Quote:

Originally Posted by loco

I have found this link.
http://www.accdata.co.uk/dwarfism/index.html
and then to the field the history of dwarfism.

Only CONSEAL and DENIAL by the breeders off the GS

.

Groette Martine.

Forgot to say, also pointing finger at other breeders

.
Does not help to cure this disease, only serieus help for the test does that.

So in the furture, when you think there is any suspicious in the line's you want to use you can ask for test results

.
And that is the only way to take this disease out of the whole breed of CSW.
Because the history off CSW is the same, in the rest off Europe as it is for CZ

.
History is something that can not be changed

.

Groette Martine.

Hanka · 25-09-2008, 21:22

Yes, but first we can try to find if some family or line has this problem. My personal meaning in this moment is: it can be from some saarlos what was used in csw breeding. But we can´t know it 100%...We can only think about it.

loco · 25-09-2008, 21:45

And we can also think

.
That it come's from the GS in the beginning

???

As the link says it is from the earlier 50s that it came out in the open, and when is the beginning of the breed CSW started??

Does it matter ? ??

It is here and it does not dissapear by pointing a finger to somebody or specific bloodline's.
Or do you think the Breed of CSW is big enough to put out specific bloodline's of breeding??

By using the test with goodtestresult you still can use all bloodline's

.

Groette Martine.

13-09-2008, 23:44	#1
mijke Senior Member Join Date: Sep 2003 Location: Warnsveld Posts: 2,033	Dwarfism test for CSW? As some of you may already know the university in Utrecht (NL) has developed a test, which can determine the mutation of the gene that is responsible for dwarfism (achondroplasia). Dwarfism is a nasty disorder which you don’t wish upon any breeder or dog. A dwarf has a badly developed hypophysis, which means that certain hormones (such as growth hormones) are not produced. Due to the shortage of the production of the thyroid stimulating hormone, they have a slow functioning thyroid. Besides the fact that these dogs stay small, they are also haunted by various nasty side effects (e.g. baldness, itching, inflammations, malfunctioning of the liver and kidneys, slow behaviour) when they are not treated with medicines on a daily basis. One case of dwarfism is known to me within the CSW breed. Because this kind of gene mutations never come incidentally, there must have been born more dwarf CSW. (If one dwarf dog is born, then it means that approximately 18% of the dogs is carrying the gene.) But not always dwarfs are recognised in a litter… Dead born pups and pups behind in growth are often not recognised as dwarfs. Moreover, 90% of the living born dwarfs dies in the first week. With the Saarloos wolfdog it has already become clear that this disorder appears much more than ever thought. Based on the genetic basis of CSW, it is feared that it could be the same in the CSW breed. But with the development of the dwarfism test it has become possible to prevent further dwarfs being born within certain breeds! I’ve heard from the researchers at the Utrecht university (who are working on this subject since years), that the mutation that leads to dwarfism in the Saarlooswolfdog breed is identical to the one of the German shepherd. So the gen test is exactly the same for the German shepherd as well as the Saarlooswolfdog. Based on the fact that the CSW also has the German shepherd as an ancestor, it is certainly feasible that the genetic background of dwarfism in the CSW breed is exactly the same as with the Saarloos wolfdog. In this case the same dwarfism test can be used for the CSW breed as well! But…. To see if the genetic mutation of the CSW has the same background, it must be determined that at least one dog is carrying this mutation. Therefore Blood is needed from at least one dog which is suffering from dwarfism, or which is certainly carrying the mutated gene by being the parent of a dwarf dog. Thus: I am doing an urgent appeal for the health of the breed to all readers of this forum to contact me by personal message or by e-mail ([email protected]) in case you know somebody who has a CSW with dwarfism or a parent of one. I do not care about the names of the dogs! My only hope is to find owners who are willing to cooperate, to determine if the new dwarfism test is also valid for CSW I can give those owners more information after they have contact me. With this request I do not intent to start up suggestions or speculations about the possibility that a breeder may has had a dwarf in his or her litter! The only request I have is to connect me with owners of a dwarf TW or owners who have a parent of dwarf CSW. If we find owners who are willing to cooperate and the results of the tests are known, I will of course inform everyone here at the forum. In advance I would like to thank you for your cooperation! Best regards, Mijke __________________ Vriendelijke groeten, Mijke PS: I am not a moderator anymore!!

25-09-2008, 14:48	#3
loco Non active. Join Date: Nov 2006 Location: Outside, walking the dog. Posts: 2,873	I have found this link. http://www.accdata.co.uk/dwarfism/index.html and then to the field the history of dwarfism. Only CONSEAL and DENIAL by the breeders off the GS . Hope the CSW world is very diffrent , and the test is very soon availble . Groette Martine. __________________ Just treat stupid situations like a dog.....If you can't play with it or eat it....... Then just piss on it and walk away .

25-09-2008, 21:45	#8
loco Non active. Join Date: Nov 2006 Location: Outside, walking the dog. Posts: 2,873	And we can also think . That it come's from the GS in the beginning ??? As the link says it is from the earlier 50s that it came out in the open, and when is the beginning of the breed CSW started?? Does it matter ? ?? It is here and it does not dissapear by pointing a finger to somebody or specific bloodline's. Or do you think the Breed of CSW is big enough to put out specific bloodline's of breeding?? By using the test with goodtestresult you still can use all bloodline's . Groette Martine. __________________ Just treat stupid situations like a dog.....If you can't play with it or eat it....... Then just piss on it and walk away .

14-09-2008, 00:07	#2
GalomyOak Howling Member Join Date: Jun 2007 Location: Colorado Posts: 436	Very nice!!! I hope you find someone that will help you! Marcy

25-09-2008, 20:30	#4
Hanka Senior Member Join Date: Nov 2003 Location: Kadaň Posts: 1,622	Hello Mijke, I have seen this picture on saarlos page, it is very interest for me. Please can you write me (maybe privat message) in what litter you have seen this csw? Maybe we can look for in "blood" of this puppy. Have you got any fotos? I have seen a some similar case, but on foto of saarlos it looks very diferent.....more worse....thanks Hanka

25-09-2008, 20:32	#5
Hanka Senior Member Join Date: Nov 2003 Location: Kadaň Posts: 1,622	And second question: is it possible- this puppy was from some "pure breed" breeding of csw in west Evropa? Everybody know, there is possible everything. Can there be any saarlos in population of csw?

25-09-2008, 21:22	#7
Hanka Senior Member Join Date: Nov 2003 Location: Kadaň Posts: 1,622	Yes, but first we can try to find if some family or line has this problem. My personal meaning in this moment is: it can be from some saarlos what was used in csw breeding. But we can´t know it 100%...We can only think about it.