Lethal genes in CzWs

Nebulosa · 19/04/2006, 04h46

Any about lethal genes in this breed?
Albinism, melanism, never have apeared one case of these pigment problems in CzWs?
Only for curiosity, already had cases of eyes Odd (( one blue other ambar, or one blue other black/ heterogeneous colors ) in CzWs?

greetings

Paula

Hanka · 19/04/2006, 11h17

Hello, I am in breeder comission in czech republic. I never heared about it. Sometimes is epilepsy, white nail... But albinismus or coloured eyes... No.

Nebulosa · 19/04/2006, 19h20

Is much good reading this!!

And about the epilepsy, what dogs have make pupies with this problems or one date that show one statistic of this problem in this breed, has as to know this?

Thank you very much!

Koos · 19/04/2006, 20h33

I think, that there will be some lethal genes, but because the breed is still so young, that it will not come out at this moment.

Maybe in 5 till 10 years there will be some come out but breeders have to keep their eyes open to see what is happening in their litters and look to several other dogs and litters, what is happening.

Still they have to "read" the pedigrees from different studdogs to breed with.

Letty from Holland

Dharkwolf · 19/04/2006, 23h40

Lethal genes are actually very hard to spot - and deserve to be explained a little better.

Albinism - already a rare condition - is certainly not a lethal gene - dogs of several breeds are born and can live with this gene. Certainly not terribly well and probably not as long as a normal dog, but they are actually born. (Hypothetically Albinism could be lethal to wolfdogs - as no albino wolfdogs have ever been born. On the other hand, and far more likely, the allele for albinism is simply not present in the CSV genetic pool)

A lethal gene is usually defined as a gene which prevents the foetus from actually being born - you either get still birth or else there is actually no conception at all.

The classical example is that of coat colour in mice - the YY (as opposed to Yy) is actually a lethal combination for that allele - no mice will ever be born which carry a YY gene combination as it is lethal.

Formal Medelean genetics will tell you that you need to look for the various ratios of allelic expressions - if you find a situation where a cross between two heterozygotes results in a 2:1 phenotype ratio - then you've probably found a lethal gene expression (normally you would expect to find either a 3:1 for traditional dominant/recessive alleles or a 1:2:1 expression pattern for codominant genes)

Unfortunately there are very few if any traits which to my knowledge have been identified in CSVs as corresponding to an allele - certainly there are some generic ones (such as coat colour) but the Wolfdog gene pool seems to be remarkably homogeneous at least in what observable traits there are (ie all wolfdogs have agouti type fur etc)

If someone has an idea on traits or lists of traits which can be found in wolfdogs and are known or reasonably suspected to be linked to an allele I would be very interested in learning more about that.

Oh and a word on lethal genes - I am not sure that it is something which breeders need to be worried about or overly concerned over - if you accidentally stumble across a lethal gene expression pattern that pup will never be born and you will probably never know about the fact. However it is certainly a fascinating subject.

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19/04/2006, 04h46	#1
Nebulosa Moderator Date d'inscription: October 2004 Localisation: Rio Grande do Sul Messages: 1 334	Any about lethal genes in this breed? Albinism, melanism, never have apeared one case of these pigment problems in CzWs? Only for curiosity, already had cases of eyes Odd (( one blue other ambar, or one blue other black/ heterogeneous colors ) in CzWs? greetings Paula

19/04/2006, 11h17	#2
Hanka Senior Member Date d'inscription: November 2003 Localisation: Kadaň Messages: 1 622	Hello, I am in breeder comission in czech republic. I never heared about it. Sometimes is epilepsy, white nail... But albinismus or coloured eyes... No.

19/04/2006, 19h20	#3
Nebulosa Moderator Date d'inscription: October 2004 Localisation: Rio Grande do Sul Messages: 1 334	Is much good reading this!! And about the epilepsy, what dogs have make pupies with this problems or one date that show one statistic of this problem in this breed, has as to know this? Thank you very much!

19/04/2006, 20h33	#4
Koos Member Date d'inscription: December 2003 Messages: 731	I think, that there will be some lethal genes, but because the breed is still so young, that it will not come out at this moment. Maybe in 5 till 10 years there will be some come out but breeders have to keep their eyes open to see what is happening in their litters and look to several other dogs and litters, what is happening. Still they have to "read" the pedigrees from different studdogs to breed with. Letty from Holland

19/04/2006, 23h40	#5
Dharkwolf Junior Member Date d'inscription: November 2004 Localisation: Brussels Messages: 201	Lethal genes are actually very hard to spot - and deserve to be explained a little better. Albinism - already a rare condition - is certainly not a lethal gene - dogs of several breeds are born and can live with this gene. Certainly not terribly well and probably not as long as a normal dog, but they are actually born. (Hypothetically Albinism could be lethal to wolfdogs - as no albino wolfdogs have ever been born. On the other hand, and far more likely, the allele for albinism is simply not present in the CSV genetic pool) A lethal gene is usually defined as a gene which prevents the foetus from actually being born - you either get still birth or else there is actually no conception at all. The classical example is that of coat colour in mice - the YY (as opposed to Yy) is actually a lethal combination for that allele - no mice will ever be born which carry a YY gene combination as it is lethal. Formal Medelean genetics will tell you that you need to look for the various ratios of allelic expressions - if you find a situation where a cross between two heterozygotes results in a 2:1 phenotype ratio - then you've probably found a lethal gene expression (normally you would expect to find either a 3:1 for traditional dominant/recessive alleles or a 1:2:1 expression pattern for codominant genes) Unfortunately there are very few if any traits which to my knowledge have been identified in CSVs as corresponding to an allele - certainly there are some generic ones (such as coat colour) but the Wolfdog gene pool seems to be remarkably homogeneous at least in what observable traits there are (ie all wolfdogs have agouti type fur etc) If someone has an idea on traits or lists of traits which can be found in wolfdogs and are known or reasonably suspected to be linked to an allele I would be very interested in learning more about that. Oh and a word on lethal genes - I am not sure that it is something which breeders need to be worried about or overly concerned over - if you accidentally stumble across a lethal gene expression pattern that pup will never be born and you will probably never know about the fact. However it is certainly a fascinating subject.