Quote:
Originally Posted by elf
Grackle, who carries one copy of
the proline deletion in TYRP1 (Table 3), was black and white,
and her closest brown German Longhair ancestor is six gen-
erations back.
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How many generations in CSW? I am not saying it is a de novo mutation, but not taking that possibility into account means we believe, that there was intentional mixing in a well known and established kennel.
Between the creation of the breed and nowadays, there was at least one bottleneck, maybe several, that caused high relatedness in the breed. Such a visible trait, as the red/brown color is, would be noticed before, if it came from GSD, no?
And de novo mutations do occur all the time, we just usually do not see them. Maybe the authors of the paper did not take them into account just because the dog that had the unusual allele, was related to brown animals in just a few generations back. And may it was a mistake not to take possibility of de novo mutation, but it actually was not the scope of the paper to ponder the origins of the mutations, but only their presence and mechanism of their action.
But, the testing for the color allele would say a lot I think, so that's the fastest way to get any answers regarding Thalia and Sibir right now. If they do not find the mutations tested nowadays, that will tell us something. If they find the one that is also present in SAV, that tells us something too. If they find two different mutations, that again tells us a lot.