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Originally Posted by saschia
OK, I am reading now the original papewr on the TYRP1 mutations causing bb phenotype, so more to come, but from what I understood untill now, they are loss-of-function kind of mutations, which actually can occur de novo.
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We know by experience in the breed (high inbreeding level) that the probability have to be ultra low, IMHO in this case with all associated problems around, this should not be researched as first evidences.
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Originally Posted by Lorry - MLS
- Maybe, Daniela will determine if there Saarloos in these 3 dogs ?
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This is difficult as if you don't fit a current research program, universities won't put a cent on this. So right now the effort should be put on DNA parentage testing.
Won't breeding clubs, with help of law(?), could help going in this direction ? Implication regarding number of offspring is scaring...